Building a Webserver for Sponge RNA Interactions in Cancer

 
Advances in sequencing technologies have revealed that there is a large number of RNAs that do not encode proteins. A major class of non-coding RNAs is long non-coding RNAs (lncRNAs).Recent work has provided evidence for an emerging regulatory role of lncRNAs. By sequestering miRNAs, lncRNAs can reduce the number of miRNAs available for the target mRNA; in this way, they indirectly prevent the target gene repression, acting like a sponge. In our previous work [1], we develop an informative approach for discovering sponge interactions. This project will involve implementing a web server to display the sponge interactions discovered.
[1]. G. Olgun, O. Sahin, and O. Tastan 2018. Discovering lncRNA mediated sponge interactions in breast cancer molecular subtypes, BMC Genomics, 19,1, pp 650.