Design and fabrication of drug delivery systems

Drug delivery is process where a drug substance is released to achieve a therapeutic effect in humans or animals. Since it is expensive and complicated to synthesize, fabricate new systems to study and discover and finally market new drug entities computatinal models to study new drug delivery systems with control over drug release is an important and challenging topic. Extensive work has been carried out in order to have spatial and temporal control over drug release from delivery systems in the body; enhance and maintain quality of drug delivery systems during fabrication and storage; protect drug from physiological degradation; improve patient compliance and therapeutic outcome. While designing such release systems, it is important to identify and understand mechanisms involved in the release process. Mathematical analysis and modelling of the dissolution data/ release rates is used to accurately predict the drug release from the drug products which can ultimately help to optimize the design of a new drug delivery systems with desired therapeutic efficacy and safety. The goal of this project is to develop computational models based on MATLAB and FEA simulation tools to study and simulate a chosen drug delivery system and compare it with experimental/theoretical results.